This investigation working with human saliva and findings have been published on 15 September in the journal Clinical Cancer Research, published by the American Association of Cancer Study.
"Not only affects cancer cells by inhibiting the signal pathway, curcumin also have an effect on saliva by reducing cytokine enzyme, which causes inflammation present in saliva," said Dr.. Marilene Wang researcher at UCLA's Jonsson Comprehensive Cancer Center of the ScienceDaily quoted as saying on Thursday (09/15/2011).
Turmeric is often a spice which is widely utilised in South Asia, East Asia, and Central Asia for cooking and has long been known to have medicinal properties, which have anti-inflammatory properties.
Prior studies have shown that curcumin can suppress the growth of specific cancers. For years, girls in India have applied turmeric as a topical anti-aging medicine, treat cramps in the course of menstruation and as a poultice on the skin to speed healing of wounds.
"A 2005 study conducted by Dr. Wang and his team showed that curcumin suppresses the growth of head and neck cancer in mice. In animal studies, curcumin is applied directly towards the tumor inside the type of a paste. Investigation in 2010 which is also completed on mouse cells identified that curcumin suppress the growth of head and neck cancer by regulating cell cycle, "said Eri Srivatsan, professor of surgery plus the Jonsson Cancer Center researcher who has been studying curcumin and its anti-cancer for seven years with Dr.. Wang.
Curcumin binds to and prevents an enzyme recognized as an inhibitor of kappa ß kinase (IKK) which promotes cancer growth. In this study, 21 patients with head and neck cancer gave saliva samples before and after they chewed two tablets of 1,000 milligrams of curcumin. An hour later, the saliva sample was taken and extracted for measuring protein kinase activity of IKKß.
Consuming curcumin not simply make contact using the cancer, but also with saliva, and this investigation shows that it reduces the levels of cytokines in exacerbating cancer.
"An independent laboratory in Maryland confirmed that the cytokines in saliva promote inflammation and support to feed the cancer. Nevertheless, the cytokine decreased in patients who chew and curcumin inhibits cell signaling pathways that trigger cancer growth," stated Wang.
Curcumin has a important inhibitory impact, blocking the two triggers the growth of cancers of the head and neck cancers are distinctive. The researchers think that curcumin may be combined with other remedies for instance chemotherapy and radiation to treat head and neck cancer. It can also be given to patients at high risk for head and neck cancer, ie smokers, people who like to chew tobacco, and patients with HPV infection.
To be productive in fighting cancer, curcumin must be employed in supplement form. Though turmeric is utilised in cooking, the quantity of curcumin is necessary to generate a considerably higher clinical effect. "Expecting a positive effect by means of eating foods spiced with turmeric isn't realistic," Wang stated.
The subsequent step for Dr. Wang and his team is treating patients with curcumin for a longer time and see its inhibitory impact is usually elevated. They strategy to treat cancer patients scheduled for the next few weeks will have surgery. They are going to perform a biopsy just before the administration of curcumin and in the time of surgery after which analyze the network to look for differences inside the effect.
"There's possible for supporting development of curcumin as a treatment for cancer patients. Curcumin just isn't toxic, well tolerated, affordable and effortlessly offered at health food shops. Though this study is promising, you will need to expand the discovery so that additional patients to confirm our findings," explains Dr. Wang.
Trying to find other approaches to treat head and neck cancer is extremely important due to the fact patients usually require surgery and miss partially tongue or mouth. Side effects that seem an excessive amount of, which includes difficulty swallowing, dry mouth and oral cancer has the potential to have one more later on.
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